Should a ketogenic diet (<50 g/day carbohydrate) be recommended for adults with type 2 diabetes?
Diet, high-protein low-carbohydrate
Diabetes Mellitus, Type 2
Glycated hemoglobin A
type 2 diabetes
DATABASES and Grey Literature Sources (e.g. international guidelines) Searched
Reasons for excluding reviews or studies identified using a hierarchical literature search
McArdle PD, Greenfield SM, Rilstone SK, Narendran P, Haque MS, Gill PS. Carbohydrate restriction for glycaemic control in Type 2 diabetes: a systematic review and meta-analysis. Diabet Med. 2019 Mar;36(3):335-348. doi: 10.1111/dme.13862. Epub 2019 Jan 3. Abstract available from: https://www.ncbi.nlm.nih.gov/pubmed/30426553
This review did a subgroup analysis examining effects of a very low carbohydrate diet (20-50 g/day), but had limited patient important outcomes (i.e. reported only A1C and body weight).
van Zuuren EJ, Fedorowicz Z, Kuijpers T, Pijl H. Effects of low-carbohydrate- compared with low-fat-diet interventions on metabolic control in people with type 2 diabetes: a systematic review including GRADE assessments. Am J Clin Nutr. 2018 Aug 1;108(2):300-331. doi: 10.1093/ajcn/nqy096. Abstract available from: https://www.ncbi.nlm.nih.gov/pubmed/30007275
This review did not examine separately the effects of a very low carbohydrate diet.
Sainsbury E, Kizirian NV, Partridge SR, Gill T, Colagiuri S, Gibson AA. Effect of dietary carbohydrate restriction on glycemic control in adults with diabetes: A systematic review and meta-analysis. Diabetes Res Clin Pract. 2018 May;139:239-252. doi: 10.1016/j.diabres.2018.02.026. Epub 2018 Mar 6. Abstract available from: https://www.ncbi.nlm.nih.gov/pubmed/29522789
This review did not focus on ketogenic diet: it included only three of the trials in the ketogenic diet arm and did not give reasons for excluding the other trials reported in the included review.
DATE of Search
Date Search Completed: June 2019
Search Limits (e.g. date, language): English language, 2005+