Content
Is vitamin D recommended for treating COVID-19?
SEARCH TERMS
MeSH Terms
Vitamin D
Cholecalciferol
Ergocalciferols
25-Hydroxyvitamin D2
Calcifediol
COVID-19
Text Words
N/A
DATABASES and Grey Literature Sources (e.g. international guidelines) Searched
PubMed
TRIP
Epistemonikos
Google Scholar
Reasons for excluding reviews or studies identified using a hierarchical literature search
Zaazouee MS, Eleisawy M, Abdalalaziz AM, Elhady MM, Ali OA, Abdelbari TM, Hasan SM, Almadhoon HW, Ahmed AY, Fassad AS, Elgendy R, Abdel-Baset EA, Elsayed HA, Elsnhory AB, Abdraboh AB, Faragalla HM, Elshanbary AA, Kensara OA, Abdel-Daim MM. Hospital and laboratory outcomes of patients with COVID-19 who received vitamin D supplementation: a systematic review and meta-analysis of randomized controlled trials. Naunyn Schmiedebergs Arch Pharmacol. 2022 Dec 12:1–14. doi: 10.1007/s00210-022-02360-x. Epub ahead of print. PMID: 36508011; PMCID: PMC9743115.
-Nine RCTs; only ICU admission and vitamin D levels assessed – few patient important outcomes
Kümmel LS, Krumbein H, Fragkou PC, Hünerbein BL, Reiter R, Papathanasiou KA, Thölken C, Weiss ST, Renz H, Skevaki C. Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials. Front Immunol. 2022 Oct 31;13:1023903. doi: 10.3389/fimmu.2022.1023903. PMID: 36389703; PMCID: PMC9659578.
- 8 RCTs (searched to Sept 2021) – include mortality, hospitalization; used GRADE – less current
Eight
Feiner Solís Á, Avedillo Salas A, Luesma Bartolomé MJ, Santander Ballestín S. The Effects of Vitamin D Supplementation in COVID-19 Patients: A Systematic Review. Int J Mol Sci. 2022 Oct 17;23(20):12424. doi: 10.3390/ijms232012424. PMID: 36293279; PMCID: PMC9604062.
- Low AMSTAR (no QA assessment)
D'Ecclesiis O, Gavioli C, Martinoli C, Raimondi S, Chiocca S, Miccolo C, Bossi P, Cortinovis D, Chiaradonna F, Palorini R, Faciotti F, Bellerba F, Canova S, Jemos C, Salé EO, Gaeta A, Zerbato B, Gnagnarella P, Gandini S. Vitamin D and SARS-CoV2 infection, severity and mortality: A systematic review and meta-analysis. PLoS One. 2022 Jul 6;17(7):e0268396. doi: 10.1371/journal.pone.0268396. PMID: 35793346; PMCID: PMC9258852.
- Searched to April 2021 combined 2 RCT and 27 cohorts (low AMSTAR)
Hosseini B, El Abd A, Ducharme FM. Effects of Vitamin D Supplementation on COVID-19 Related Outcomes: A Systematic Review and Meta-Analysis. Nutrients. 2022 May 20;14(10):2134. doi: 10.3390/nu14102134. PMID: 35631275; PMCID: PMC9147949.
- Searched to Jan 2022 Primary prevention (1 RCT, 4 NRS); secondary prevention (6 RCTS, 7 NRS) (low AMSTAR)
Beran A, Mhanna M, Srour O, Ayesh H, Stewart JM, Hjouj M, Khokher W, Mhanna AS, Ghazaleh D, Khader Y, Sayeh W, Assaly R. Clinical significance of micronutrient supplements in patients with coronavirus disease 2019: A comprehensive systematic review and meta-analysis. Clin Nutr ESPEN. 2022 Apr;48:167-177. doi: 10.1016/j.clnesp.2021.12.033. Epub 2022 Jan 13. PMID: 35331487; PMCID: PMC8755558.
- Searched to Dec 2021 (combined 10 RCTS and 16 observation) , vit C, D, Zinc; meta-analysis combined RCTS and observ. (low AMSTAR)
Hu Y, Kung J, Cave A, Banh HL. Effects of Vitamin D Serum Level on Morbidity and Mortality in Patients with COVID-19: A Systematic Review and Meta-Analysis. J Pharm Pharm Sci. 2022;25:84-92. doi: 10.18433/jpps32590. PMID: 35245430.
- 20 studies combined RCTs and NRS (low AMSTAR)
Varikasuvu SR, Thangappazham B, Vykunta A, Duggina P, Manne M, Raj H, Aloori S. COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials. Expert Rev Anti Infect Ther. 2022 Jun;20(6):907-913. doi: 10.1080/14787210.2022.2035217. Epub 2022 Feb 3. PMID: 35086394; PMCID: PMC8862170.
- Search date not reported; n=6 RCTs (low AMSTAR)
Tentolouris N, Samakidou G, Eleftheriadou I, Tentolouris A, Jude EB. The effect of vitamin D supplementation on mortality and intensive care unit admission of COVID-19 patients. A systematic review, meta-analysis and meta-regression. Diabetes Metab Res Rev. 2022 May;38(4):e3517. doi: 10.1002/dmrr.3517. Epub 2022 Jan 15. PMID: 34965318; PMCID: PMC9015406.
-searched to March 2021 (combined RCTs and NRS) – included in Shah 2022 SR
Dissanayake HA, de Silva NL, Sumanatilleke M, de Silva SDN, Gamage KKK, Dematapitiya C, Kuruppu DC, Ranasinghe P, Pathmanathan S, Katulanda P. Prognostic and Therapeutic Role of Vitamin D in COVID-19: Systematic Review and Meta-analysis. J Clin Endocrinol Metab. 2022 Apr 19;107(5):1484-1502. doi: 10.1210/clinem/dgab892. PMID: 34894254; PMCID: PMC8689831.
- Searched to May 2021 (combined RCTs and NRS); 72 observational and 4 RCTs (low AMSTAR)
Szarpak L, Filipiak KJ, Gasecka A, Gawel W, Koziel D, Jaguszewski MJ, Chmielewski J, Gozhenko A, Bielski K, Wroblewski P, Savytskyi I, Szarpak L, Rafique Z. Vitamin D supplementation to treat SARS-CoV-2 positive patients. Evidence from meta-analysis. Cardiol J. 2022;29(2):188-196. doi: 10.5603/CJ.a2021.0122. Epub 2021 Oct 13. PMID: 34642923; PMCID: PMC9007480.
- Searched to July 2021 (2 RCTs and 6 NRS) (low AMSTAR)
Pal R, Banerjee M, Bhadada SK, Shetty AJ, Singh B, Vyas A. Vitamin D supplementation and clinical outcomes in COVID-19: a systematic review and meta-analysis. J Endocrinol Invest. 2022 Jan;45(1):53-68. doi: 10.1007/s40618-021-01614-4. Epub 2021 Jun 24. PMID: 34165766; PMCID: PMC8223190.
- Searched to June 2021 (10 observation, 3 RCTs) – included in Shah 2022 SR
DATE of Search
Date Search Completed: February 2023
Search Limits (e.g. date, language): 2018-present, English language